Here are the most recent, relevant updates I can confirm right now for interferon-inducible GTPase 5 (GBP5/IFN-inducible GTPase 5). The newest item I found in available sources is a 2025 paper describing a mechanism of antiviral activity via inhibition of viral glycoprotein N-linked glycosylation.[1]
If you tell me whether you mean human GBP5 specifically (gene GBP5) or whether you want mouse vs human, I can narrow the “latest news” to the exact organism and disease area (e.g., COVID-19, HIV, inflammasome/NLRP3, cancer immunology).
Interferon (IFN)-induced guanosine triphosphate hydrolysing enzymes (GTPases) have been identified as cornerstones of IFN-mediated cell-autonomous defence. Upon IFN stimulation, these GTPases are highly expressed in various host cells, where they ...
pmc.ncbi.nlm.nih.govCell-autonomous immunity is essential for host organisms to defend themselves against invasive microbes. In vertebrates, both the adaptive and the innate branches of the immune system operate cell-autonomous defenses as key effector mechanisms that ...
pmc.ncbi.nlm.nih.govViral infection induces production of type I interferons and expression of interferon-stimulated genes (ISGs) that play key roles in inhibiting viral infection. Here, we show that the ISG guanylate-binding protein 5 (GBP5) inhibits N-linked ...
pmc.ncbi.nlm.nih.gov