Three infections, one fight: an implementation study to map needle prevalence and evaluate HIV, syphilis and hepatitis C prevention interventions in Regina, Saskatchewan – a protocol

Introduction

Saskatchewan faces a serious public health crisis with high rates of HIV, syphilis, and hepatitis C virus (HCV) infections, especially among people who use drugs. Injection drug use significantly drives these overlapping epidemics, worsened by challenges such as stigma, poverty, and a lack of culturally safe healthcare. There is an urgent need for innovative, community-informed strategies to enhance prevention, testing, and linkage to care.

Methods and Analysis

This study will implement a rapid assessment and response system in Regina, Saskatchewan, combining geospatial mapping of needle distribution with mobile pop-up interventions. Maps identifying needle hotspots will guide community-based events providing point-of-care testing for HIV, syphilis, and HCV, along with education on pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP).

A convergent participatory mixed-methods approach will evaluate the feasibility, acceptability, and effectiveness of the intervention. The study will use the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework for guidance.

"This study integrates geospatial mapping with community events to better reach populations affected by injection drug use and improve prevention efforts for HIV, syphilis, and hepatitis C."

Author's summary: This study employs geospatial mapping and community pop-ups in Regina to enhance HIV, syphilis, and hepatitis C prevention among drug users, aiming to improve testing, education, and care access.

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BMJ Open BMJ Open — 2025-11-05