Think melatonin is safe? New research reveals a hidden heart risk

Long-Term Melatonin Use May Pose Heart Risks

New research suggests that prolonged melatonin use for sleep issues could increase the risk of serious heart problems. Chronic users were found to be nearly twice as likely to die and 3.5 times more likely to be hospitalized for heart failure.

Study Findings on Melatonin and Heart Failure

A preliminary study presented at the American Heart Association's (AHA) Scientific Sessions 2025 revealed that adults with chronic insomnia who used melatonin for a year or more had higher chances of developing heart failure, experiencing hospitalizations related to heart failure, and dying from any cause compared to those who did not use melatonin.

This study was featured at the AHA’s annual meeting held from November 7 to 10 in New Orleans, a key global event for cardiovascular science and clinical updates.

What is Melatonin?

Melatonin is a hormone produced by the pineal gland that controls the sleep-wake cycle, increasing in the dark and decreasing in daylight. Synthetic melatonin, identical to the natural hormone, is commonly used to treat insomnia and jet lag in many countries.

In the U.S., melatonin supplements are available over the counter without prescription. However, they are not regulated by the FDA, which means product quality, dosage, and purity can vary significantly.

"People who regularly take melatonin to improve sleep may face serious health risks," researchers warn.

Expert Recommendations

Despite melatonin’s reputation as a harmless supplement, experts now advise caution in its long-term use, especially for people with chronic insomnia or other sleep disorders.

Author's summary: Long-term melatonin use, often considered safe, may significantly increase heart failure risk and mortality, urging careful medical guidance for continual use.

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ScienceDaily ScienceDaily — 2025-11-04

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