Heart Health: Long-Term Melatonin Use Linked to Cardiovascular Risk

New research indicates that individuals with insomnia who take melatonin supplements for over a year may face an increased risk of heart failure compared to those who do not use the sleep aid. The study found that long-term melatonin users were more likely to receive a heart failure diagnosis, be hospitalized for it, or die from any cause.

Study Overview

The findings were shared at the American Heart Association’s Scientific Sessions 2025 in New Orleans. This preliminary research has yet to be published in a peer-reviewed journal. While it does not confirm a direct cause-and-effect link between melatonin and heart failure, it raises important safety concerns.

Concerns About Regulation and Use

Researchers emphasized that melatonin supplements are widely available over the counter without prescription and lack regulatory oversight. This means many people use them without medical supervision.

“Melatonin supplements may not be as harmless as commonly assumed.”

Implications for Future Research

The study suggests the need for more in-depth investigation into the cardiovascular safety of long-term melatonin use, especially given its widespread availability and use.

Summary

Long-term melatonin supplementation could pose cardiovascular risks, highlighting the importance of medical guidance and further research on its safety.

Author's summary: Extended melatonin use may increase heart failure risk, underscoring the need for cautious use and further cardiovascular safety studies.

Healthline — 2025-11-05