Long-term use of melatonin supplements to support sleep may have negative health effects

Long-term Use of Melatonin Supplements May Pose Health Risks

A review of five years of health data involving over 130,000 adults with insomnia who used melatonin for at least one year revealed increased risks linked to the supplement's prolonged use.

Key Findings

Study Context

This preliminary research was scheduled for presentation at the American Heart Association’s Scientific Sessions 2025, held in New Orleans from November 7 to 10. The event serves as a major forum for sharing cutting-edge scientific developments and clinical updates in cardiovascular science.

About Melatonin

Melatonin is a hormone naturally produced by the pineal gland that regulates the body's sleep-wake cycle by rising in darkness and falling with daylight.

Synthetic melatonin supplements, chemically identical to the natural hormone, are commonly used to combat insomnia and jet lag. These supplements are readily accessible over the counter in many countries, including the United States.

Regulatory Notes

In the U.S., melatonin supplements do not require government approval, resulting in variability in strength, purity, and quality across different brands.

Melatonin is "a hormone naturally produced in the body by the pineal gland, and it helps regulate the body’s sleep-wake cycle."
The supplements are "widely available over the counter in many countries, including the U.S.," but their quality can vary due to lack of regulatory oversight.

Author’s summary: Prolonged use of melatonin supplements may increase heart failure risks and mortality in insomnia patients, highlighting the need for cautious and informed use of these widely accessible products.

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www.heart.org www.heart.org — 2025-11-03

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