Melatonin users have 90% higher chance of developing heart failure, twice as likely to die: New study | Mint

Melatonin Use Linked to Higher Heart Failure Risk

A recent study indicates that long-term melatonin use may raise the risk of developing heart failure by up to 90% in adults suffering from insomnia. Those who regularly used the supplement were also more likely to be hospitalized or die within five years compared with non-users.

Details of the Research

Melatonin is one of the most popular over-the-counter sleep aids in the United States, used by nearly six million Americans to improve sleep quality. However, findings presented at the American Heart Association (AHA) Scientific Sessions 2025 suggest prolonged use could pose serious health risks.

“Adults with insomnia who took melatonin for at least one year had a significantly higher likelihood of developing heart failure,” researchers reported.

The research analyzed medical records of more than 130,000 adults diagnosed with insomnia who had no prior history of heart failure. Participants who consumed melatonin for over a year were compared with those who never used the supplement. Results showed a 90% increase in heart failure risk among long-term users.

International Perspective

In the United Kingdom, melatonin can only be obtained with a prescription. Among patients who filled at least two prescriptions 90 days apart, the study still observed an 82% higher risk of heart failure.

“Long-term melatonin users were nearly 3.5 times more likely to be hospitalized for heart failure than non-users,” the study concluded.
Summary

Long-term melatonin use may substantially increase heart failure risk, highlighting the need for medical supervision even with commonly used sleep aids.

Author’s summary: The study warns that prolonged melatonin intake could significantly raise risks of heart failure, hospitalization, and death among adults with insomnia.

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Mint Mint — 2025-11-08

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